Genes and Society in the News:
- New Science for the People group—Piece in Science Magazine. April 4
- New Study of high altitude adaptation in Tibetans where they found 7 additional variants – PNAS, Early Edition. April 3.
- Razib Khan also wrote a blog post in Gene Expression, April 4, on this topic
- Gene Editing of human embryos yields early results– ScienceNews, March 29. This describes the work of both Chinese and American studies.
- Debrief on Precious Little- Central Conversation afterwards with Dr. Shoumita Dasgupta, Director of Graduate Studies, Genetics and Genomics at Boston University.
- Related conversations/announcements sparked in GSWG group:
Articles for Discussion:
- Naik, R. P., Irvin, M. R., Judd, S., Gutiérrez, O. M., Zakai, N. A., Derebail, V. K., . . . Cushman, M. (2017). Sickle Cell Trait and the Risk of ESRD in Blacks. Journal of the American Society of Nephrology. doi:10.1681/asn.2016101086
- Accompanying report in Medpage Today.
- Meaning of “person years”
- Discussion of NCAA testing. (Why not focus on hydrated practices for all?)
- Self-report of race—related to known ancestry
- Are they including/controlling for other factors that affect kidney disease (lifestyle factors?) How matched are the populations?
- Used blacks in this study because of health disparity- higher incidence of end-stage renal disease
- Limitation- can be something else in the haplotype linked to SCT. (Candidate gene/association, not causative)
- There are kidney diseases related to hypertension; there’s more hypertension in African Americans (another health disparity)
- In bigger picture, studies like these (or attempts to understand disease in general where the approach includes breaking down in relationship to race) reify race. Or, is this not an issue with this study in that self-identified blacks composed study and control group.