Genes and Society in the News:
- Gina Kolata. “With a Simple DNA Test, Family Histories Are Rewritten.” New York Times, Aug 28, 2017.
- Harry, Pettit. “A portrait without ever seeing your face: Scientists create a realistic mugshot using just your DNA.” Dailymail, September 5, 2017.
- Yaniv Erlich. “Major flaws in ‘Identification of individuals by trait prediction using whole-genome’. Biorxiv, September 6, 2017.
- Erika Check Hayden. “Tomorrow’s Children.” Nature, February 23, 2016.
- Adam Hargreaves. “Introducing ‘dark DNA’ – the phenomenon that could change how we think about evolution.” The Conversation, August 24, 2017.
- Linda Rodriguez McRobbie. “Do it yourself DNA? go right ahead.” Boston Globe, August 25, 2017.
- Hagai Shpigler, et al. “Deep evolutionary conservation of autism-related genes.” PNAS, June 26, 2017.
- Cristina Quinn. “Could genetically engineered mice reduce Lyme disease?” PBS News Hour, September 12, 2017.
- Kevin Lewis. “Uncommon Knowledge: Creationism and bull markets.” The Boston Globe, August 25, 2017.
- September/October issue. Rowan Jacobsen. Mother Jones. “A Future of Genetically Engineered Children Is Closer Than You’d Think.” Latest of a series of articles in Mother Jones on genetic engineering. In the same issue, but print only, “Debugging the Planet,” by Michael Mechanis, on the ethical issues around eliminating mosquitoes (or others) using gene drive.
- August 25. Bonnie Rochman. The Washington Post. “Five Myths about Gene Editing” Responds in part to the Mother Jones article.
Article for Discussion:
- Lim et al. Rates, distribution and implications of postzygotic mosaic mutations in autism spectrum disorder. Nature Neuroscience
- We focused on the original Nature Neuroscience article. It reports that 7.5% of de novo, or non-inherited, mutations in people with autism spectrum disorder (ASD) appear in only some of the body’s cells, based on analysis of sequences from nearly 20,000 people.
- Many of these affect the amygdala, which is involved in formation and storage of memories associated with emotional events, thus plausibly with ASD. Previous studies missed most of these mosaic mutations. Conclusion that PZMs constitute a significant proportion of de novo mutations and contribute importantly to ASD risk.
- General agreement that the article not clearly written, especially with its free use of technical terms not necessarily defined clearly or widely understood––trio, ASD proband, etc.
- Some questions about the diagnosis of ASD and even its definition, e.g., one or many disorders? social shaping, especially in schools? differential diagnosis by class and ethnicity?