Genes and Society in the News:
- Oct 11, 2017. GenomeWeb. Self-CRISPRing? Josiah Zaynor demonstrates self experimentation with CRISPR
- All in one bacterial gene engineering CRISPR kit. Demonstrating/teaching CRISPR technique to engineer a bacterial streptomycin resistance change
- Oct 9, 2017. Oliver Moody. Times London. NASA wants to protect DNA of Mars Crew
- Douglas Terrier, NASA’s acting chief technologist, said that the organization was investigating drugs that might repair the damage to DNA and was open to the possibility of tweaking genetic activity or altering genes
- July 20, 2017. Tina Hesman Saey. ScienceNews. Resistance to CRISPR gene drives may arise easily.
- Oct 14. Jonathan Hahn. Sierra Club Bulletin. Book Review of Carey Gillam’s Whitewash: The Story of a Weed Killer, Cancer and the Corruption of Science.
- Oct. 13. BioRxiv Preprint. Paleo-Eskimo genetic legacy across North America.
- An example of using an ancient DNA comparator along with modern descendent populations to learn about the genetic history possible historical migrations that founded modern populations.
- Gene Therapy for an inherited blindness in Phase 3 Clinical trial.
- Efficacy and safety of voretigene neparvovec (AAV2-hRPE65v2) in patients with RPE65-mediated inherited retinal dystrophy: a randomised, controlled, open-label, phase 3 trial. Russell, Stephen et al. The Lancet , Volume 390 , Issue 10097 , 849 – 860
- September 13. SingularityHub. Shelly Fan. FDA Breaks Ground with First Approved Gene Therapy for Cancer. Uses a disabled HIV virus as vector.
Article for Discussion:
- October 4, 2017. Tielbeek et al. Genome-wide Association Studies of a Broad Spectrum of Antisocial Behavior. JAMA Psychiatry
- Predictive power of ASB mentioned in the conclusions is concerning. This is balanced, somewhat, in the preceding paragraph on authors listing of the study limitations.
- Sample size is small for gene finding purposes.
- Article is a meta-analysis study with a wide variability of measures used for ASB traits. Some studies in this meta-analysis use separate male and female populations and behaviors for identification of the SNPs.
- Reference is cited (Rhee and Waldman, 2002) with claim from twin and adoption studies that 50% of the variance in ASB is explained by genetic factors
- With this small sample size, the polygenic score of 5-10% of the variance accounted for may be questionable.
- Author’s do not favor candidate gene approaches but support GWAS approach
- No notice of press coverage on this, something to look out for.
- Munafo co-author here. Ioannadis and Munafo often co-authors on validation of meta-studies, statistical power of GWAS studies or failure of reproducibility in studies.