Genes and Society in the News
- NYTimes Book Review by Jennifer Raif of Carl Zimmer’s new book “She has her mother’s laugh”
- Article about omnigene theory – Though very large numbers of genes are involved in”complex traits”, including common diseases, there will be some “core genes” that can be found.
- A new paper suggests modifications to this theory
- Wray, N. R., Wijmenga, C., Sullivan, P. F., Yang, J., & Visscher, P. M. (2018). Common Disease Is More Complex Than Implied by the Core Gene Omnigenic Model. Cell, 173(7), 1573-1580. doi:10.1016/j.cell.2018.05.051
- Materials about genes and IQ.
- Article in MIT Technology Review about the search for genes involved in intelligence
- One of the featured papers: Sniekers, S., Stringer, S., Watanabe, K., Jansen, P. R., Coleman, J. R., Krapohl, E., . . . Posthuma, D. (2017). Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence. Nature Genetics, 49(7), 1107-1112. doi:10.1038/ng.3869
- These next two articles were referred to in a 6/25/2018 tweet from Joe Pickrell: “Two preprints argue that the most-replicated signal of polygenic adaptation in humans (on height within Europe) may partially (or even completely?) be an artifact of uncorrected population structure in the main height GWAS”
- Ioannidis: “most research is flawed” (from Medscape)
- Family DNA Testing at the Border Would Be an Ethical Quagmire | WIRED
- We discussed the complications of much of the recent work, which relies heavily on big data and statistics. This makes it difficult to understand and more difficult to explain. At the last meeting Pankaj Mehta explained his opinion that many of the current analyses and big statements are based on small effects. He discussed the need for explaining some of the concepts with simple diagrams and simulations. This would be a challenge for us but we might get somewhere collecting some of the materials presented by others – typically in blogs often referred to on twitter. In this regard Graham Coop has posted some interesting materials that explain some of the non-intuitive results also presented in Reich’s book.