Nov 7, 2018 Meeting

Genes and Society in the News:

GWAS and Polygenic Scores Discussion:

  • There are questions around statistics. It seems that larger and larger GWAS studies are needed.
  • There are questions as to how regression coefficients are used.
    • Do you analyze each SNP separately? Suggestion is that regression correlations are done for each SNP to a trait of interest. Polygenic score is additive effects of SNPS.
    • Brian discussed nested populations and PCA as ways by which allele frequency differences due to ancestry can be controlled for.


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